3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane

Base Information

• Chemical Name: 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane
• CAS No.: 1369957-03-8
• Molecular Formula: C₂₃H₃₁N₅O
• Molecular Weight: 393.532

Synonyms:3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane

Chemical Property of 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane

Chemical Property:

Purity/Quality:

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Technology Process of 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane

There total 3 articles about 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-phenylmethyl-2-{[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]methyl}aziridine (1369956-97-7) + diethyl amine hydrochloride (660-68-4) → 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane (1369957-03-8)

Guidance literature:

With diethylamine; In acetonitrile; at 140 ℃; for 2h; regioselective reaction; Microwave irradiation;

DOI:10.3762/bjoc.7.205

Reference yield:

N-benzyl-2-(bromomethyl)aziridine (25662-24-2) → 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane (1369957-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / dimethyl sulfoxide / 16 h / 20 - 80 °C

2: copper(l) iodide / acetonitrile / 16 h / 20 °C / Reflux

3: diethylamine / acetonitrile / 2 h / 140 °C / Microwave irradiation

With copper(l) iodide; sodium azide; diethylamine; In dimethyl sulfoxide; acetonitrile;

DOI:10.3762/bjoc.7.205

Reference yield:

2-azidomethyl-1-(phenylmethyl)aziridine (1369956-88-6) + 4-methoxyphenylacetylen (768-60-5) → 3-diethylamino-2-(phenylmethyl)amino-1-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]propane (1369957-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide / acetonitrile / 16 h / 20 °C / Reflux

2: diethylamine / acetonitrile / 2 h / 140 °C / Microwave irradiation

With copper(l) iodide; diethylamine; In acetonitrile;

DOI:10.3762/bjoc.7.205

upstream raw materials:

1-phenylmethyl-2-{[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]methyl}aziridine

diethyl amine hydrochloride

2-azidomethyl-1-(phenylmethyl)aziridine

4-methoxyphenylacetylen

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