1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

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Chemical Name:1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea
CAS No.:1555700-60-1
Molecular Formula:C₂₃H₂₇F₃N₄O₂
Molecular Weight:448.488
Hs Code.:

Synonyms:1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

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Chemical Property of 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

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Technology Process of 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

There total 8 articles about 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1555700-58-7
1-(1-benzylpiperidin-4-yl)-3-{2-[7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]phenyl}urea

: 1555700-60-1
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

Guidance literature:: 1-(1-benzylpiperidin-4-yl)-3-{2-[7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]phenyl}urea; With palladium on activated charcoal; hydrogen; In methanol; for 2h;

With hydrogen; ammonium formate; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; water; for 16h;

Reference yield:

: 1555700-55-4
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

: 1555700-60-1
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide; tetrahydrofuran / 0.33 h / 150 °C / Microwave irradiation

2.1: palladium on activated charcoal; hydrogen / methanol / 2 h

2.2: 16 h / 20 °C

2.3: 16 h

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: 400-99-7
2-nitro-4-trifluoromethylphenol

: 1555700-60-1
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-(piperidin-4-yl)urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C

2.2: 1.33 h

3.1: sulfuric acid / ethanol / 24 h / 0 - 20 °C

3.2: 0.5 h / 0 °C

4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 48 h / 120 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 120 h

6.1: dichloromethane / 19 h / 20 °C

7.1: dimethyl sulfoxide; tetrahydrofuran / 0.33 h / 150 °C / Microwave irradiation

8.1: palladium on activated charcoal; hydrogen / methanol / 2 h

8.2: 16 h / 20 °C

8.3: 16 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; palladium on activated charcoal; hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;