2-(Benzyloxy)-5-(trifluoromethyl)aniline

Base Information

Chemical Name:2-(Benzyloxy)-5-(trifluoromethyl)aniline
CAS No.:117901-14-1
Molecular Formula:C14H12F3NO
Molecular Weight:267.24600
Hs Code.:
DSSTox Substance ID:DTXSID40350652
Wikidata:Q82126702
Mol file:117901-14-1.mol

Synonyms:2-(BENZYLOXY)-5-(TRIFLUOROMETHYL)ANILINE;117901-14-1;2-phenylmethoxy-5-(trifluoromethyl)aniline;TimTec1_004251;SCHEMBL6080280;DTXSID40350652;HMS1546B05;AKOS000214853;SB81709;CS-0270070;EN300-207992;SR-01000520690;SR-01000520690-1

Suppliers and Price of 2-(Benzyloxy)-5-(trifluoromethyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-(Benzyloxy)-5-(trifluoromethyl)aniline
500mg
$ 205.00

American Custom Chemicals Corporation
2-(BENZYLOXY)-5-(TRIFLUOROMETHYL)ANILINE 95.00%
500MG
$ 802.73

Total 3 raw suppliers

Chemical Property of 2-(Benzyloxy)-5-(trifluoromethyl)aniline

Chemical Property:

PSA：35.25000
LogP:4.44780
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:267.08709849
Heavy Atom Count:19
Complexity:276

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzyloxy)-5-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=C(C=C(C=C2)C(F)(F)F)N

Technology Process of 2-(Benzyloxy)-5-(trifluoromethyl)aniline

There total 4 articles about 2-(Benzyloxy)-5-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 400-99-7
2-nitro-4-trifluoromethylphenol

: 100-39-0
benzyl bromide

: 117901-14-1
2-(benzyloxy)-5-(trifluoromethyl)aniline

Guidance literature:: 2-nitro-4-trifluoromethylphenol; benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With ammonium chloride; zinc; In ethanol; at 20 ℃; for 16h;

Reference yield:

: 135328-55-1
4-benzyloxy-3-nitrobenzene

: 117901-14-1
2-(benzyloxy)-5-(trifluoromethyl)aniline

Guidance literature:: With ammonium chloride; zinc; In ethanol; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.bioorg.2021.105244

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 117901-14-1
2-(benzyloxy)-5-(trifluoromethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 - 80 °C

2: zinc; ammonium chloride / ethanol / 24 h / Inert atmosphere; Reflux

With potassium carbonate; ammonium chloride; zinc; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2021.105244