1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Base Information

Chemical Name:1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea
CAS No.:1555700-55-4
Molecular Formula:C₂₁H₂₄F₃N₃O₂
Molecular Weight:407.436
Hs Code.:

Synonyms:1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Suppliers and Price of 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

There total 6 articles about 1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1555699-29-0
1-(2-aminophenyl)-3,3-dimethyl-4-(trifluoromethyl)indolin-7-ol

: 1795-48-8
Isopropyl isocyanate

: 1555700-55-4
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Guidance literature:: In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 400-99-7
2-nitro-4-trifluoromethylphenol

: 1555700-55-4
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C

2.2: 1.33 h

3.1: sulfuric acid / ethanol / 24 h / 0 - 20 °C

3.2: 0.5 h / 0 °C

4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 48 h / 120 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 120 h

6.1: dichloromethane / 19 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1555699-22-3
(2-(benzyloxy)-5-(trifluoromethyl)phenyl)hydrazine trifluoroacetate

: 1555700-55-4
1-(2-(7-hydroxy-3,3-dimethyl-4-(trifluoromethyl)indolin-1-yl)phenyl)-3-isopropylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / ethanol / 24 h / 0 - 20 °C

1.2: 0.5 h / 0 °C

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 48 h / 120 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 120 h

4.1: dichloromethane / 19 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; dichloromethane; ethyl acetate; toluene;