6--2,3,4-trimethoxy-acetophenon

Base Information

• Chemical Name: 6--2,3,4-trimethoxy-acetophenon
• CAS No.: 95868-60-3
• Molecular Formula: C₂₅H₂₄O₇
• Molecular Weight: 436.461
• Mol file: 95868-60-3.mol

Synonyms:6--2,3,4-trimethoxy-acetophenon

Chemical Property of 6--2,3,4-trimethoxy-acetophenon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6--2,3,4-trimethoxy-acetophenon

There total 6 articles about 6--2,3,4-trimethoxy-acetophenon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyloxy)benzoic acid chloride (1486-50-6) + 6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) → 6--2,3,4-trimethoxy-acetophenon (95868-60-3)

Guidance literature:

With pyridine; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.11.034

Reference yield:

p-(benzyloxy)benzoic acid (1486-51-7) → 6--2,3,4-trimethoxy-acetophenon (95868-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 °C

2: pyridine / 15 h / 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.tetlet.2011.11.034

Reference yield:

4-hydroxy-benzoic acid (99-96-7) → 6--2,3,4-trimethoxy-acetophenon (95868-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol; water / 24 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 °C

3: pyridine / 15 h / 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; potassium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1016/j.tetlet.2011.11.034

upstream raw materials:

4-(benzyloxy)benzoic acid chloride

6-hydroxy-2,3,4-trimethoxyacetophenone

3,4,5-trimethoxyphenol

p-(benzyloxy)benzoic acid

Downstream raw materials:

2-(4-benzyloxy-phenyl)-5,6,7-trimethoxy-chromen-4-one

salvigenin

2-(4-(benzyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one

C₃₁H₃₂O₁₅