C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

Base Information

Chemical Name:C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine
CAS No.:1287761-19-6
Molecular Formula:C₁₅H₂₁N₃O₂S
Molecular Weight:307.417
Hs Code.:

Synonyms:C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

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Chemical Property of C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

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Technology Process of C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

There total 6 articles about C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1287761-18-5
3-azidomethyl-5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazole

: 1287761-19-6
C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 2h;
DOI:10.1021/jm2001376

Reference yield:

: 75-97-8
3,3-dimethyl-butan-2-one

: 1287761-19-6
C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: ethanol / 20 °C / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5.1: sodium azide / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

With lithium aluminium tetrahydride; sodium azide; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate;
DOI:10.1021/jm2001376

Reference yield:

: C₁₆H₂₂N₂O₅S₂

: 1287761-19-6
C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

With sodium azide; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/jm2001376