1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

Base Information

Chemical Name:1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea
CAS No.:1287760-91-1
Molecular Formula:C₂₃H₂₅F₃N₄O₃S
Molecular Weight:494.538
Hs Code.:

Synonyms:1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

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Chemical Property of 1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

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Technology Process of 1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

There total 7 articles about 1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1287761-19-6
C-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-yl]methylamine

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1287760-91-1
1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm2001376

Reference yield:

: C₁₆H₂₂N₂O₅S₂

: 1287760-91-1
1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

3: triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm2001376

Reference yield:

: 75-97-8
3,3-dimethyl-butan-2-one

: 1287760-91-1
1-[5-tert-butyl-1-(4-methanesulfonylphenyl)-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: ethanol / 20 °C / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5.1: sodium azide / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

7.1: triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium azide; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm2001376