3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

Base Information

Chemical Name:3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole
CAS No.:1402140-69-5
Molecular Formula:C₂₄H₁₈F₃NO₂
Molecular Weight:409.408
Hs Code.:

Synonyms:3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

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Chemical Property of 3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

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Technology Process of 3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

There total 3 articles about 3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1402140-58-2
(1Z)-1-[4-(trifluoromethyl)phenyl]-3-phenyl-2-propyn-1-one O-[(4-methoxyphenyl)methyl]oxime

: 1402140-69-5
3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In chlorobenzene; at 20 ℃; for 2.5h; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/jo301358h

Reference yield: 76.0%

: 1402140-77-5
(1Z)-1,3-diphenyl-2-propyn-1-one O-[[4-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]phenyl]methyl]oxime

: 1402140-58-2
(1Z)-1-[4-(trifluoromethyl)phenyl]-3-phenyl-2-propyn-1-one O-[(4-methoxyphenyl)methyl]oxime

: 1402140-68-4
3,5-diphenyl-4-[(4-methoxyphenyl)methyl]isoxazole

: 1402140-69-5
3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

: 1402140-85-5
4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

: 1402140-91-3
3-[4-(trifluoromethyl)phenyl]-4-[4-[[(1,1-dimethylethyl)-dimethylsilyloxy]phenyl]methyl]-5-phenylisoxazole

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In chlorobenzene; at 20 ℃; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/jo301358h

Reference yield:

: 21038-22-2
O-(4-methoxybenzyl)hydroxylamine

: 1402140-69-5
3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / ethanol / 12 h / Reflux

2: copper(II) bis(trifluoromethanesulfonate) / chlorobenzene / 2.5 h / 20 °C / Inert atmosphere; Reflux

With pyridinium p-toluenesulfonate; copper(II) bis(trifluoromethanesulfonate); In ethanol; chlorobenzene;
DOI:10.1021/jo301358h