4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

Base Information

Chemical Name:4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole
CAS No.:1402140-85-5
Molecular Formula:C₂₈H₃₁NO₂Si
Molecular Weight:441.645
Hs Code.:

Synonyms:4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

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Chemical Property of 4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

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Technology Process of 4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

There total 3 articles about 4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1402140-77-5
(1Z)-1,3-diphenyl-2-propyn-1-one O-[[4-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]phenyl]methyl]oxime

: 1402140-85-5
4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In chlorobenzene; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/jo301358h

Reference yield: 76.0%

: 1402140-77-5
(1Z)-1,3-diphenyl-2-propyn-1-one O-[[4-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]phenyl]methyl]oxime

: 1402140-58-2
(1Z)-1-[4-(trifluoromethyl)phenyl]-3-phenyl-2-propyn-1-one O-[(4-methoxyphenyl)methyl]oxime

: 1402140-68-4
3,5-diphenyl-4-[(4-methoxyphenyl)methyl]isoxazole

: 1402140-69-5
3-[4-(trifluoromethyl)phenyl]-4-[(4-methoxyphenyl)methyl]-5-phenylisoxazole

: 1402140-85-5
4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

: 1402140-91-3
3-[4-(trifluoromethyl)phenyl]-4-[4-[[(1,1-dimethylethyl)-dimethylsilyloxy]phenyl]methyl]-5-phenylisoxazole

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In chlorobenzene; at 20 ℃; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/jo301358h

Reference yield:

: 7338-94-5
1,3-diphenyl-2-propynone

: 250602-93-8
O-[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]hydroxylamine

: 1402140-85-5
4-[4-[[(1,1-dimethylethyl)dimethylsilyloxy]phenyl]methyl]-3,5-diphenylisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / ethanol / 12 h / Reflux

2: copper(II) bis(trifluoromethanesulfonate) / chlorobenzene / 2 h / 20 °C / Inert atmosphere; Reflux

With pyridinium p-toluenesulfonate; copper(II) bis(trifluoromethanesulfonate); In ethanol; chlorobenzene;
DOI:10.1021/jo301358h