N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

Base Information

Chemical Name:N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine
CAS No.:1421632-81-6
Molecular Formula:C₃₅H₃₇N₅O₆S
Molecular Weight:655.775
Hs Code.:

N<sub>2</sub>-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

Synonyms:N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

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Chemical Property of N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

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Technology Process of N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

There total 14 articles about N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1609117-77-2
3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

: 1421632-81-6
5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Guidance literature:: With sodium hydroxide; In ethanol; for 1h;
DOI:10.1002/anie.201310644

Reference yield:

: 934980-57-1
N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine

: 1421632-81-6
N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 1.08333h; Inert atmosphere;
DOI:10.1039/c2ob26940f

Reference yield:

: 825638-98-0
C₃₅H₃₅N₅O₇

: 1421632-81-6
N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / dichloromethane; isopropyl alcohol / -60 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4.5 h / 0 - 20 °C / Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran; methanol / 1.08 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; water; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; 2: |Mitsunobu Displacement;
DOI:10.1039/c2ob26940f