3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Base Information

Chemical Name:3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine
CAS No.:1609117-77-2
Molecular Formula:C₃₇H₃₉N₅O₇S
Molecular Weight:697.812
Hs Code.:

Synonyms:3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Suppliers and Price of 3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

There total 4 articles about 3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 170236-39-2
5-O-(4,4-dimethoxytriphenyl)-N-2-isobutyryl-2-desoxyxyloguanosine

: 507-09-5
tiolacetic acid

: 1609117-77-2
3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201310644

Reference yield:

: 170236-40-5
5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine

: 1609117-77-2
3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 2 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 0 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310644

Reference yield:

: 121513-00-6
3-O-benzoyl-2-desoxyxyloguanosine

: 1609117-77-2
3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / 20 °C

2: sodium hydroxide / ethanol / 2 h

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 0 °C / Inert atmosphere

With pyridine; di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310644