1-Methoxy-3,7-dimethylpyrrolo[1,2-A]pyrazine

Base Information

• Chemical Name: 1-Methoxy-3,7-dimethylpyrrolo[1,2-A]pyrazine
• CAS No.: 95407-89-9
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.218
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20540913
• Wikidata: Q82417050
• Mol file: 95407-89-9.mol

Synonyms:1-METHOXY-3,7-DIMETHYLPYRROLO[1,2-A]PYRAZINE;95407-89-9;DTXSID20540913

Chemical Property of 1-Methoxy-3,7-dimethylpyrrolo[1,2-A]pyrazine

Chemical Property:

• PSA: 26.53000
• LogP: 1.95970
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 176.094963011
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN2C=C(N=C(C2=C1)OC)C

Technology Process of 1-Methoxy-3,7-dimethylpyrrolo[1,2-A]pyrazine

There total 3 articles about 1-Methoxy-3,7-dimethylpyrrolo[1,2-A]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methoxy-2,5-dimethyl-1-(2-oxo-propyl)-pyrazin-1-ium; bromide → 3,7-dimethyl-2-methoxypyrrolo<1,2-a>pyrazine (95407-89-9)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.5h; Yield given; Heating;

DOI:10.1021/jo00208a042

Reference yield:

3-methoxyl-2,5-dimethylpyrazine (19846-22-1) → 3,7-dimethyl-2-methoxypyrrolo<1,2-a>pyrazine (95407-89-9)

Guidance literature:

Multi-step reaction with 2 steps

2: NaHCO₃ / H₂O / 0.5 h / Heating

With sodium hydrogencarbonate; In water;

DOI:10.1021/jo00208a042

Reference yield:

1-bromoacetone (598-31-2) + 3-methoxyl-2,5-dimethylpyrazine (19846-22-1) → 3,7-dimethyl-2-methoxypyrrolo<1,2-a>pyrazine (95407-89-9) + 3,7-dimethylpyrrolo<1,2-a>pyrazin=1(2H)-one (144951-19-9)

Guidance literature:

With sodium hydrogencarbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) 45 deg C, 10 d, 2.) water, reflux;

DOI:10.3987/COM-92-6085

upstream raw materials:

1-bromoacetone

3-methoxyl-2,5-dimethylpyrazine