(3,4-Dichlorophenyl)-trimethylsilanyloxy-acetonitrile

Base Information

Chemical Name:(3,4-Dichlorophenyl)-trimethylsilanyloxy-acetonitrile
CAS No.:95392-03-3
Molecular Formula:C11H13 Cl2 N O Si
Molecular Weight:274.222
Hs Code.:2931900090
DSSTox Substance ID:DTXSID80594093
Mol file:95392-03-3.mol

Synonyms:95392-03-3;(3,4-dichlorophenyl)-trimethylsilanyloxy-acetonitrile;SCHEMBL7087812;DTXSID80594093;AKOS011844306;(3,4-Dichlorophenyl)[(trimethylsilyl)oxy]acetonitrile;(3,4-DICHLORO-PHENYL)-TRIMETHYLSILANYLOXY-ACETONITRILE

Suppliers and Price of (3,4-Dichlorophenyl)-trimethylsilanyloxy-acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (3,4-Dichlorophenyl)-trimethylsilanyloxy-acetonitrile

Chemical Property:

PSA：33.02000
LogP:4.40958
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:273.0143460
Heavy Atom Count:16
Complexity:283

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[Si](C)(C)OC(C#N)C1=CC(=C(C=C1)Cl)Cl

Technology Process of (3,4-Dichlorophenyl)-trimethylsilanyloxy-acetonitrile

There total 2 articles about (3,4-Dichlorophenyl)-trimethylsilanyloxy-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 7677-24-9
trimethylsilyl cyanide

: 6287-38-3
3,4-dichlorobenzaldehyde

: 95392-03-3
2-(3,4-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:: With triethylamine; at 20 ℃; for 24h;
DOI:10.1021/acs.jmedchem.9b00445

Reference yield: 95.0%

: 177755-45-2
2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile

: 6287-38-3
3,4-dichlorobenzaldehyde

: 95392-03-3
2-(3,4-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile

Guidance literature:

Reference yield: 49.0%

: 100-39-0
benzyl bromide

: 95392-03-3
2-(3,4-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile

: 93534-22-6
1-(3,4-dichlorophenyl)-2-phenyl-ethan-1-one

Guidance literature:: benzyl bromide; 2-(3,4-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 24h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;
DOI:10.1021/acs.jmedchem.9b00445