2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester

Base Information

• Chemical Name: 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester
• CAS No.: 287720-49-4
• Molecular Formula: C₁₁H₁₈O₂
• Molecular Weight: 182.263
• Mol file: 287720-49-4.mol

Synonyms:2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester

Chemical Property of 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester

There total 3 articles about 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + (2RS)-2-<(1R)-4-methylcyclohex-3-enyl>propanoic acid (287720-48-3) → 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester (287720-49-4)

Guidance literature:

With sulfuric acid; at 60 ℃; for 4h;

DOI:10.1002/hlca.19960790606

Reference yield:

(2RS)-2-<(1R)-4-methylcyclohex-3-enyl>propanol (287720-47-2) → 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester (287720-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / PDC / dimethylformamide / 12 h / 20 °C

2: 92 percent / H₂SO₄ / 4 h / 60 °C

With dipyridinium dichromate; sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19960790606

Reference yield:

D-limonene (5989-27-5,555-08-8,8022-90-0,9003-73-0,95327-98-3) → 2-((R)-4-Methyl-cyclohex-3-enyl)-propionic acid methyl ester (287720-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 9-BBN, 2.) 6M NaOH, 30percent H₂O₂ / 1.) THF, 2.) EtOH, 1 h, 50 deg C

2: 39 percent / PDC / dimethylformamide / 12 h / 20 °C

3: 92 percent / H₂SO₄ / 4 h / 60 °C

With sodium hydroxide; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19960790606

upstream raw materials:

methanol

(2RS)-2-<(1R)-4-methylcyclohex-3-enyl>propanoic acid

D-limonene

(2RS)-2-<(1R)-4-methylcyclohex-3-enyl>propanol