4-(4-NITRO-PHENOXY)-PIPERIDINE

Base Information

• Chemical Name: 4-(4-NITRO-PHENOXY)-PIPERIDINE
• CAS No.: 162402-39-3
• Molecular Formula: C11H14N2O3
• Molecular Weight: 222.244
• Hs Code.: 2933399090
• Mol file: 162402-39-3.mol

Synonyms:4-(4-NITRO-PHENOXY)-PIPERIDINE;4-(4-Nitrophenyloxy)piperidine;4-(4-Piperidinyl)oxy-1-nitrobenzene

Chemical Property of 4-(4-NITRO-PHENOXY)-PIPERIDINE

Chemical Property:

• PSA: 67.08000
• LogP: 2.57760

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Nitrophenoxy)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-NITRO-PHENOXY)-PIPERIDINE

There total 7 articles about 4-(4-NITRO-PHENOXY)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → 4-(4-nitrophenoxy)piperidine (162402-39-3)

Guidance literature:

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate; With trifluoroacetic acid; at 20 ℃; for 1h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield: 87.0%

→ 4-(4-nitrophenoxy)piperidine (162402-39-3)

Guidance literature:

Reference yield: 61.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(4-nitrophenoxy)piperidine (162402-39-3)

Guidance literature:

4-nitro-phenol; t-butyl 4-hydroxy piperidine-1-carboxylate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 48h;

With trifluoroacetic acid; at 20 ℃; for 1h;

With sodium hydroxide; In water;

upstream raw materials:

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

4-nitro-phenol

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

Downstream raw materials:

4-(1-cyclobutylpiperidin-4-yloxy)-1-nitrobenzene

1-cyclopentyl -4-(4-nitrophenoxy)piperidine

1-cyclopropyl-4-(4-nitrophenoxy)piperidine

1-ethyl-3-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)urea

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