Technology Process of 2-methoxy-6-[4-methyl-3-(triisopropylsilyloxy)phenylamino]benzonitrile
There total 2 articles about 2-methoxy-6-[4-methyl-3-(triisopropylsilyloxy)phenylamino]benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate;
In
toluene;
for 18h;
Inert atmosphere;
Reflux;
DOI:10.1002/ejoc.201402201
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 19 h / Inert atmosphere; Reflux
2: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate / toluene / 18 h / Inert atmosphere; Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; caesium carbonate;
In
N,N-dimethyl-formamide; toluene;
2: |Buchwald-Hartwig Coupling;
DOI:10.1002/ejoc.201402201
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; palladium diacetate; trimethylpyruvic acid; copper diacetate / 18.5 h / 100 °C
2: diisobutylaluminium hydride / dichloromethane; hexane / -78 - -30 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / -15 - 20 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; copper diacetate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; trimethylpyruvic acid;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201402201
