6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

Base Information

Chemical Name:6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)
CAS No.:1056010-75-3
Molecular Formula:C₂₃H₂₅ClN₄O₅
Molecular Weight:472.928
Hs Code.:

Synonyms:6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

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Chemical Property of 6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

Chemical Property:

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Technology Process of 6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

There total 4 articles about 6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 807640-59-1
1,3-dioxolane-2-methanamine, N-[(2-amino-4-chlorophenyl)methyl]-N-methyl-

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1056010-75-3
6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

Guidance literature:: 1,3-dioxolane-2-methanamine, N-[(2-amino-4-chlorophenyl)methyl]-N-methyl-; 6-acetoxy-4-chloro-7-methoxyquinazoline; In acetonitrile; at 80 ℃; for 4h;

With acetic acid; In acetonitrile; at 80 ℃;

Reference yield:

: 5551-11-1
4-Chloro-2-nitrobenzaldehyde

: 1056010-75-3
6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

Guidance literature:: Multi-step reaction with 2 steps

1.1: thiophene; hydrogen / platinum on activated charcoal / tetrahydrofuran; methanol; ethyl acetate / 50 °C

2.1: acetonitrile / 4 h / 80 °C

2.2: 80 °C

With thiophene; hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile;

Reference yield:

: 57366-77-5
1-(1,3-dioxolan-2-yl)-N-methylmethanamine

: 1056010-75-3
6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-, acetate (ester)

Guidance literature:: Multi-step reaction with 2 steps

1.1: thiophene; hydrogen / platinum on activated charcoal / tetrahydrofuran; methanol; ethyl acetate / 50 °C

2.1: acetonitrile / 4 h / 80 °C

2.2: 80 °C

With thiophene; hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile;