carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester
CAS No.:1056010-76-4
Molecular Formula:C₂₉H₃₈ClN₅O₆
Molecular Weight:588.104
Hs Code.:

carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

Synonyms:carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

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Chemical Property of carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

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Technology Process of carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

There total 7 articles about carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1056010-76-4
carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 4 h / 80 °C

1.2: 80 °C

2.1: methanol; ammonia / 1 h / 20 °C

3.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

With methanol; ammonia; caesium carbonate; In DMF (N,N-dimethyl-formamide); acetonitrile;

Reference yield:

: 807640-60-4
6-quinazolinol, 4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 1056010-76-4
carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

Reference yield:

: 5551-11-1
4-Chloro-2-nitrobenzaldehyde

: 1056010-76-4
carbamic acid, [3-[[4-[[5-chloro-2-[[(1,3-dioxolan-2-ylmethyl)methylamino]methyl]phenyl]amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: thiophene; hydrogen / platinum on activated charcoal / tetrahydrofuran; methanol; ethyl acetate / 50 °C

2.1: acetonitrile / 4 h / 80 °C

2.2: 80 °C

3.1: methanol; ammonia / 1 h / 20 °C

4.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

With thiophene; methanol; ammonia; hydrogen; caesium carbonate; platinum on activated charcoal; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); ethyl acetate; acetonitrile;