C₁₇H₁₆N₂O₂S₂

Base Information

• Chemical Name: C₁₇H₁₆N₂O₂S₂
• CAS No.: 1588511-50-5
• Molecular Formula: C₁₇H₁₆N₂O₂S₂
• Molecular Weight: 344.458
• Mol file: 1588511-50-5.mol

Synonyms:C₁₇H₁₆N₂O₂S₂

Chemical Property of C₁₇H₁₆N₂O₂S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₆N₂O₂S₂

There total 4 articles about C₁₇H₁₆N₂O₂S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-[(benzo[d]thiazol-2-ylthio)methyl]benzoic acid (100961-61-3) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → C17H16N2O2S2 (1588511-50-5)

Guidance literature:

2-[(benzo[d]thiazol-2-ylthio)methyl]benzoic acid; With thionyl chloride; In dichloromethane; at 0 - 40 ℃; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1002/ejoc.201301159

Reference yield:

2-Mercaptobenzothiazole (149-30-4,118090-09-8) → C17H16N2O2S2 (1588511-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 6 h / -30 °C

2: thionyl chloride / dichloromethane / 4 h / 0 °C / Inert atmosphere; Reflux

3: triethylamine / 3 h / 0 - 20 °C

With thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201301159

Reference yield:

2-[(benzo[d]thiazol-2-ylthio)methyl]benzoic acid (100961-61-3) → C17H16N2O2S2 (1588511-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / 0 °C / Inert atmosphere; Reflux

2: triethylamine / 3 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1002/ejoc.201301159

upstream raw materials:

2-Mercaptobenzothiazole

2-[(benzo[d]thiazol-2-ylthio)methyl]benzoic acid

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

[4-(methylthio)phenyl](2-vinylphenyl)methanone

thiophen-2-yl(2-vinylphenyl)methanone

(4-fluorophenyl)(2-vinylphenyl)methanone

phenyl(2-vinylphenyl)methanone

Refernces

• 1、 Harikrishna, Kommidi,Mukkamala, Ramesh,Hinkelmann, Bettina,Sasse, Florenz,Aidhen, Indrapal Singh. "Iodine-promoted oxidative conversion of o-vinyl diaryl ketones into o-acetyl diaryl ketones, synthesis of 1-methyl-4-arylphthalazines as analogues of podophyllotoxin". . p. 1066 - 1075. Retrieved 2015/10/05.