2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

Base Information

Chemical Name:2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline
CAS No.:1373546-81-6
Molecular Formula:C₁₈H₁₉F₃N₂
Molecular Weight:320.357
Hs Code.:

Synonyms:2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

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Chemical Property of 2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

Chemical Property:

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Technology Process of 2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

There total 4 articles about 2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373546-79-2
4,4-dimethyl-2-(2-nitrophenyl)-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline

: 1373546-81-6
2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1373546-81-6
2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 3 h / Reflux

2: boron trifluoride diethyl etherate / acetonitrile / 90 °C / sealed tube; Cooling with ice

3: ammonium chloride; iron / ethanol; water / 3 h / Inert atmosphere; Reflux

With iron; ammonium chloride; boron trifluoride diethyl etherate; In ethanol; water; acetonitrile;

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 1373546-81-6
2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 3 h / Reflux

2: boron trifluoride diethyl etherate / acetonitrile / 90 °C / sealed tube; Cooling with ice

3: ammonium chloride; iron / ethanol; water / 3 h / Inert atmosphere; Reflux

With iron; ammonium chloride; boron trifluoride diethyl etherate; In ethanol; water; acetonitrile;