<1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

Base Information

Chemical Name:<1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol
CAS No.:124128-04-7
Molecular Formula:C₁₈H₂₄OSe
Molecular Weight:335.348
Hs Code.:

Synonyms:<1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

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Chemical Property of <1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

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Technology Process of <1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

There total 6 articles about <1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 138476-93-4
((1R,2S,4aR)-4a,8-Dimethyl-2-phenylselanyl-1,2,3,4,4a,5,6,7-octahydro-naphthalen-1-yloxy)-trimethyl-silane

: 124128-04-7
<1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;

Reference yield: 70.0%

: 124127-99-7
(2RS,trans)-3,4,4a,5,6,7-hexahydro-4a,8-dimethyl-2-(phenylseleno)-1(2H)-naphthalenone

: 124128-04-7
<1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 1.33333h;
DOI:10.1021/jo00290a053

Reference yield:

: 57232-69-6
3-(4-oxopentyl)-2-cyclohexen-1-one

: 124128-04-7
<1RS-(1α,2α,4aβ)>-1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-2-(phenylseleno)-1-naphthalenol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) CuI, 2.) p-TsOH*H₂O / 2.) molecular sieves (3 Angstroem) / 1a.) ether, -78 deg C, 1.5 h, 1b.) ice-bath, 1 h, 2.) benzene, 4 h at reflux

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min

3: 70 percent / diisobutylaluminium hydride / toluene; hexane / 1.33 h / -78 °C

With copper(l) iodide; diisobutylaluminium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; 3 A molecular sieve; In hexane; toluene;
DOI:10.1021/jo00290a053