Technology Process of benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate
There total 16 articles about benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl;
In
toluene;
for 14h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / 1,4-dioxane; methanol / 14 h / 20 °C
1.2: pH 10
2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl / toluene / 14 h / Heating / reflux
With
hydrogenchloride; caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl;
In
1,4-dioxane; methanol; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / 2 h / 0 - 20 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); XPhos / tetrahydrofuran / 0.17 h
2.2: 18 h / 60 °C
3.1: tetrahydrofuran / 72 h / 75 °C
4.1: potassium carbonate / palladium diacetate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 100 °C
5.1: ammonium formate / palladium hydroxide on carbon / methanol / 2 h / Heating / reflux
6.1: triethylamine / N,N-dimethyl-formamide / 24 h
7.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl / toluene / 14 h / Heating / reflux
With
potassium tert-butylate; ammonium formate; potassium carbonate; caesium carbonate; triethylamine;
palladium diacetate; tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl; palladium hydroxide on carbon; XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;