benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

Base Information

Chemical Name:benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate
CAS No.:1067914-49-1
Molecular Formula:C₃₃H₃₅N₅O₄
Molecular Weight:565.672
Hs Code.:

Synonyms:benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

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Chemical Property of benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

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Technology Process of benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

There total 16 articles about benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 236406-15-8
(4-methyl-piperidin-4-yl)-carbamic acid benzyl ester

: 2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl trifluoromethanesulfonate

: 1067914-49-1
benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl; In toluene; for 14h; Heating / reflux;

Reference yield:

: 236406-14-7
1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate

: 1067914-49-1
benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 14 h / 20 °C

1.2: pH 10

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl / toluene / 14 h / Heating / reflux

With hydrogenchloride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; toluene;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 1067914-49-1
benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / 2 h / 0 - 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tetrahydrofuran / 0.17 h

2.2: 18 h / 60 °C

3.1: tetrahydrofuran / 72 h / 75 °C

4.1: potassium carbonate / palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C

5.1: ammonium formate / palladium hydroxide on carbon / methanol / 2 h / Heating / reflux

6.1: triethylamine / N,N-dimethyl-formamide / 24 h

7.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl / toluene / 14 h / Heating / reflux

With potassium tert-butylate; ammonium formate; potassium carbonate; caesium carbonate; triethylamine; palladium diacetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (±)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl; palladium hydroxide on carbon; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;