Isonicotinic acid, 2-ethoxy-6-hydroxy-, ethyl ester (7CI)

Base Information

• Chemical Name: Isonicotinic acid, 2-ethoxy-6-hydroxy-, ethyl ester (7CI)
• CAS No.: 91013-21-7
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.218
• Mol file: 91013-21-7.mol

Synonyms:Isonicotinicacid, 2-ethoxy-6-hydroxy-, ethyl ester (7CI)

Chemical Property of Isonicotinic acid, 2-ethoxy-6-hydroxy-, ethyl ester (7CI)

Chemical Property:

• PSA: 68.65000
• LogP: 1.36260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isonicotinic acid, 2-ethoxy-6-hydroxy-, ethyl ester (7CI)

There total 2 articles about Isonicotinic acid, 2-ethoxy-6-hydroxy-, ethyl ester (7CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

ethanol (64-17-5) + citrazinic acid (99-11-6) → ethyl 2-ethoxy-6-hydroxyisonicotinate (91013-21-7)

Guidance literature:

With sulfuric acid; for 72h; Reflux;

Reference yield:

→ ethyl 2-ethoxy-6-hydroxyisonicotinate (91013-21-7)

Guidance literature:

2,6-Dihydroxyisonicotinsaeure, wfr. A., Bzl./konz. H2SO4, Kochen;

Reference yield:

ethyl 2-ethoxy-6-hydroxyisonicotinate (91013-21-7) → 4-(bromomethyl)-2-ethoxy-6-isopropoxypyridine

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C

3.1: dimethylsulfide borane complex; Trimethyl borate / tetrahydrofuran / 18 h / 0 - 20 °C

4.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

4.2: 1 h / Reflux

With Trimethyl borate; dimethylsulfide borane complex; water; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

ethanol

citrazinic acid