methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

Base Information

Chemical Name:methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate
CAS No.:869805-62-9
Molecular Formula:C₂₁H₃₃N₃O₄
Molecular Weight:391.511
Hs Code.:

Synonyms:methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

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Chemical Property of methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

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Technology Process of methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

There total 4 articles about methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: lithium 4-(((diethylamino)ethyl)carbamoyl)benzoate

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 869805-62-9
methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

Guidance literature:: lithium 4-(((diethylamino)ethyl)carbamoyl)benzoate; With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h;

methyl (L)-leucinate hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm050181l

Reference yield:

: 120-61-6
1,4-benzenedicarboxylic acid dimethyl ester

: 869805-62-9
methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Al(CH₃)3 / CH₂Cl₂; hexane / 2 h / 0 - 5 °C

1.2: 70 percent / CH₂Cl₂; hexane / 77 h / Heating

2.1: 100 percent / aq. lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3.1: hydroxybenzotriazole; dicyclocarbodiimide; Et₃N / CH₂Cl₂ / 1 h / 0 °C

3.2: 51 percent / CH₂Cl₂ / 20 °C

With lithium hydroxide; trimethylaluminum; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm050181l

Reference yield:

: 100-36-7
N,N-diethylethylenediamine

: 869805-62-9
methyl 2-(4-(((diethylamino)ethyl)carbamoyl)benzamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Al(CH₃)3 / CH₂Cl₂; hexane / 2 h / 0 - 5 °C

1.2: 70 percent / CH₂Cl₂; hexane / 77 h / Heating

2.1: 100 percent / aq. lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3.1: hydroxybenzotriazole; dicyclocarbodiimide; Et₃N / CH₂Cl₂ / 1 h / 0 °C

3.2: 51 percent / CH₂Cl₂ / 20 °C

With lithium hydroxide; trimethylaluminum; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm050181l