1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 467443-13-6
• Molecular Formula: C₁₇H₂₂Cl₂N₂O₃
• Molecular Weight: 373.279
• Mol file: 467443-13-6.mol

Synonyms:1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

Chemical Property of 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

There total 7 articles about 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dichlorophenyl acetic acid (5807-30-7) → 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester (467443-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride

2: sodium azide / toluene / 1 h / Heating

3: CHCl₃ / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; In chloroform; toluene;

DOI:10.3797/scipharm.aut-01-204

Reference yield:

3,4-dichlorobenzyl alcohol (1805-32-9) → 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester (467443-13-6)

Guidance literature:

Multi-step reaction with 6 steps

1: PBr₃ / CH₂Cl₂

2: AcOH; H₂SO₄

3: thionyl chloride

4: sodium azide / toluene / 1 h / Heating

5: CHCl₃ / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; sulfuric acid; phosphorus tribromide; acetic acid; In dichloromethane; chloroform; toluene;

DOI:10.3797/scipharm.aut-01-204

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester (467443-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen chloride gas / Heating

2: CHCl₃ / 3 h / 0 - 20 °C

With hydrogenchloride; In chloroform;

DOI:10.3797/scipharm.aut-01-204

upstream raw materials:

1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride

1,2-dichloro-4-isocyanatomethylbenzene

3,4-dichlorophenyl acetic acid

3,4-dichlorobenzyl alcohol