Ethyl 1-aminocyclohexanecarboxylate hydrochloride

Base Information

• Chemical Name: Ethyl 1-aminocyclohexanecarboxylate hydrochloride
• CAS No.: 63203-48-5
• Molecular Formula: C9H18ClNO2
• Molecular Weight: 207.7
• Hs Code.: 2922499990
• European Community (EC) Number: 841-299-5
• DSSTox Substance ID: DTXSID80459794
• Mol file: 63203-48-5.mol

Synonyms:63203-48-5;Ethyl 1-aminocyclohexanecarboxylate hydrochloride;Ethyl 1-aminocyclohexane-1-carboxylate Hydrochloride;1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride;1-Amino-cyclohexanecarboxylic acid ethyl ester HCl;Ethyl 1-aminocyclohexanecarboxylate HCl;ethyl 1-aminocyclohexane-1-carboxylate;hydrochloride;MFCD07366916;SCHEMBL242120;DTXSID80459794;YBPDXXIYJYURHS-UHFFFAOYSA-N;AKOS015958694;DS-8873;SB38035;SY096668;CS-0045365;EN300-43194;Ethyl1-aminocyclohexanecarboxylatehydrochloride;A917570;Ethy 1-aminocyclohexancarboxylate hydrogen chloride;Ethyl 1-aminocyclohexancarboxylate hydrogen chloride;F9995-1506;Z444311400;1-aminocyclohexanecarboxylic acid ethyl ester hydrochloride;Ethyl 1-aminocyclohexane-1-carboxylate--hydrogen chloride (1/1);1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride (H-Ac6c-OEt);1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride, AldrichCPR

Chemical Property of Ethyl 1-aminocyclohexanecarboxylate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.71340
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 207.1026065
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

97% ^*data from raw suppliers

1-Amino-cyclohexanecarboxylicacidethylesterhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1(CCCCC1)N.Cl

Technology Process of Ethyl 1-aminocyclohexanecarboxylate hydrochloride

There total 2 articles about Ethyl 1-aminocyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Wang-benzaldehyde resin, imine with glycine ethyl ester + 1,5-dibromo-pentane (111-24-0) → 1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride (63203-48-5)

Guidance literature:

Wang-benzaldehyde resin, imine with glycine ethyl ester; 1,5-dibromo-pentane; In 1-methyl-pyrrolidin-2-one; for 1h;

With tert-butylimino-tri(pyrrolidino)phosphorane; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 14h;

With hydrogenchloride; In tetrahydrofuran; for 5h;

DOI:10.1039/b505881c

Reference yield:

ethanol (64-17-5) + 1-aminocyclohexane carboxylic acid (2756-85-6) → 1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride (63203-48-5)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.3797/scipharm.aut-01-204

Reference yield: 83.0%

1,3-dihydroxyacetone dimer (62147-49-3) + potassium thioacyanate (333-20-0) + 1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride (63203-48-5) → ethyl 1-(5-(hydroxymethyl)-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)cyclohexanecarboxylate

Guidance literature:

With acetic acid; In water; acetonitrile; at 60 ℃; for 16h;

DOI:10.1021/ol502845h

upstream raw materials:

ethanol

1-aminocyclohexane carboxylic acid

1,5-dibromo-pentane

Downstream raw materials:

1-[3-(4-chloro-phenyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester

1-[3-(3,4-dichloro-phenyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester