tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

Base Information

Chemical Name:tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate
CAS No.:147290-96-8
Molecular Formula:C₁₆H₂₂FN₃O₅
Molecular Weight:355.366
Hs Code.:

Synonyms:tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

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Chemical Property of tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

Chemical Property:

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Technology Process of tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

There total 4 articles about tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[tert-butoxycarbonylaminoacetyl-(2-fluoro-5-nitro-benzyl)-amino]-propionic acid tert-butyl ester

: 147290-96-8
tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 ℃; for 3h; Yield given;
DOI:10.1021/jm980166z

Reference yield:

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 147290-96-8
tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaOAc, NaBH₃CN / methanol / 2 h / Ambient temperature

2: Et₃N, BOP / CH₂Cl₂ / Ambient temperature

3: 4M aq. HCl / CH₂Cl₂; dioxane / 3 h / 0 °C

With hydrogenchloride; sodium acetate; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm980166z

Reference yield:

: 15231-41-1
tert-butyl 3-aminopropanoate

: 147290-96-8
tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-N-(2-aminoacetyl)-3-aminopropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaOAc, NaBH₃CN / methanol / 2 h / Ambient temperature

2: Et₃N, BOP / CH₂Cl₂ / Ambient temperature

3: 4M aq. HCl / CH₂Cl₂; dioxane / 3 h / 0 °C

With hydrogenchloride; sodium acetate; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm980166z