2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

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Chemical Name:2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide
CAS No.:1215105-51-3
Molecular Formula:C₃₀H₂₄FN₅O₃
Molecular Weight:521.551
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

There total 11 articles about 2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.1%

: 1215107-61-1
1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride

: 1215107-09-7
tert-butyl 3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

: 1215105-51-3
2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

Guidance literature:: tert-butyl 3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 61.1%

: 1215107-09-7
tert-butyl 3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

: 1-(pyrimidin-2-yl)cyclopropanamine hydrochloride

: 1215105-51-3
2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

Guidance literature:: tert-butyl 3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

1-(pyrimidin-2-yl)cyclopropanamine hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1215105-51-3
2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 2 h / 90 °C / Inert atmosphere

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

2.2: 1 h

3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C / flask was wrapped in aluminum foil

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

5.1: toluene / 1 h / 80 °C

6.1: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 15514.9 Torr / Parr bomb

7.1: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 60 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

9.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

9.2: 1 h / 20 °C

With N-Bromosuccinimide; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;