[6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

Base Information

Chemical Name:[6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine
CAS No.:1609937-75-8
Molecular Formula:C₂₃H₂₈N₈
Molecular Weight:416.529
Hs Code.:

Synonyms:[6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

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Chemical Property of [6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

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Technology Process of [6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

There total 10 articles about [6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1609938-40-0
(6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)-(1-methylpiperidin-4-yl)amine

: 1609938-58-0
(5-benzyl-1-methyl-1H-pyrazol-4-yl)boronic acid

: 1609937-75-8
[6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; at 90 ℃; for 1h; Inert atmosphere;

Reference yield:

: (4-bromo-2-methyl-2H-pyrazol-3-yl)(phenyl)methanol

: 1609937-75-8
[6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; triethylsilane / 16 h / 50 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

3.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran; water / 1 h / 90 °C / Inert atmosphere

With triethylsilane; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; water; 3.1: |Suzuki Coupling;

Reference yield:

: 473528-88-0
4-bromo-1-methyl-1H-pyrazole-5-carboxaldehyde

: 1609937-75-8
[6-(5-benzyl-1-methyl-1H-pyrazol-4-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]-(1-methylpiperidin-4-yl)amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.1: trifluoroacetic acid; triethylsilane / 16 h / 50 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 25 °C / Inert atmosphere

4.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran; water / 1 h / 90 °C / Inert atmosphere

With triethylsilane; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; water; 4.1: |Suzuki Coupling;