(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

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Chemical Name:(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one
CAS No.:1186017-10-6
Molecular Formula:C₂₆H₃₂N₂O₆S
Molecular Weight:500.616
Hs Code.:

Synonyms:(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

There total 4 articles about (S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186017-11-7
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

: 1186017-10-6
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; under 760.051 Torr;

Reference yield:

: 959937-90-7
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]propionic acid

: 1186017-10-6
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / diethyl ether; dichloromethane / 1.08 h / -78 - 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: 3 h / -78 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1.25 h / -78 - -40 °C

3.2: 19 h / -78 - -40 °C

4.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; methanol / 760.05 Torr

With n-butyllithium; hydrogen; triethylamine; lithium diisopropyl amide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;

Reference yield:

: C₂₈H₃₇NO₇S

: 1186017-10-6
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-hydroxy-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.25 h / -78 - -40 °C

2.2: 19 h / -78 - -40 °C

3.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; methanol / 760.05 Torr

With n-butyllithium; hydrogen; lithium diisopropyl amide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; hexane;