(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

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Chemical Name:(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one
CAS No.:1186017-11-7
Molecular Formula:C₃₄H₄₀N₂O₇S
Molecular Weight:620.767
Hs Code.:

Synonyms:(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

There total 3 articles about (S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-89-4
(S)-4-benzyl-3-{3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]propionyl}oxazolidin-2-one

: 74-88-4
methyl iodide

: 1186017-11-7
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-3-{3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]propionyl}oxazolidin-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -40 ℃; for 1.25h;

methyl iodide; In tetrahydrofuran; at -78 - -40 ℃; for 19h;

Reference yield:

: 959937-90-7
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]propionic acid

: 1186017-11-7
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / diethyl ether; dichloromethane / 1.08 h / -78 - 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: 3 h / -78 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1.25 h / -78 - -40 °C

3.2: 19 h / -78 - -40 °C

With n-butyllithium; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

Reference yield:

: C₂₈H₃₇NO₇S

: 1186017-11-7
(S)-4-benzyl-3-{(S,R)-3-[(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2-methylpropionyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.25 h / -78 - -40 °C

2.2: 19 h / -78 - -40 °C

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;