Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe

Base Information

• Chemical Name: Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe
• CAS No.: 77659-15-5
• Molecular Formula: C₃₅H₄₇N₅O₁₀
• Molecular Weight: 697.786

Synonyms:Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe

Chemical Property of Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe

Chemical Property:

Purity/Quality:

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Technology Process of Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe

There total 13 articles about Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-D-Ala-L-Leu-OMe (27167-66-4) → Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe (77659-15-5)

Guidance literature:

Multi-step reaction with 4 steps

1: HBr / acetic acid / 0.75 h

2: triethylamine / dimethylformamide; tetrahydrofuran / -30 deg C, 1 h, -10 deg C, 1 h, r.t., 2 days

3: HBr / trifluoroacetic acid / 0.5 h

4: N-methylmorpholine / dimethylformamide / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; triethylamine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1007/BF00579436

Reference yield:

Z-L-Ser-L-Tyr-OMe (24118-03-4) → Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe (77659-15-5)

Guidance literature:

Multi-step reaction with 5 steps

1: HBr / trifluoroacetic acid / 0.5 h

2: 70 percent / N-methylmorpholine / dimethylformamide / 48 h / Ambient temperature

3: 80 percent / hydrazine / methanol / Heating

4: tert-butyl nitrite, HCl / dimethylformamide; tetrahydrofuran / 0.17 h / -30 °C

5: triethylamine / dimethylformamide; tetrahydrofuran / -30 deg C, 1 h, -10 deg C, 1 h, then r.t., 2 days

With 4-methyl-morpholine; hydrogenchloride; tert.-butylnitrite; hydrogen bromide; triethylamine; hydrazine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1007/BF00579436

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-OMe (77659-15-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) isobutyl chloroformate, N-methylmorpholine

2: HBr / acetic acid / 0.75 h

3: triethylamine / dimethylformamide; tetrahydrofuran / -30 deg C, 1 h, -10 deg C, 1 h, r.t., 2 days

4: HBr / trifluoroacetic acid / 0.5 h

5: N-methylmorpholine / dimethylformamide / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1007/BF00579436

upstream raw materials:

HBr*H-D-Ala-L-Leu-OMe

Z-Pro-OPcp

Z-D-Ala-L-Leu-OMe

Z-L-Ser-L-Tyr-OMe

Downstream raw materials:

Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-N₂H₃

Z-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg(NO₂)-L-Pro-NHEt

Z-D-Phe-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt

H-L-Pro-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt

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