1,3-Dichloro-5-[(2-methoxyethoxy)methoxy]-2-(phenylmethoxy)benzene

Base Information

• Chemical Name: 1,3-Dichloro-5-[(2-methoxyethoxy)methoxy]-2-(phenylmethoxy)benzene
• CAS No.: 186805-81-2
• Molecular Formula: C₁₇H₁₈Cl₂O₄
• Molecular Weight: 357.234
• DSSTox Substance ID: DTXSID601164207
• Mol file: 186805-81-2.mol

Synonyms:DTXSID601164207;1,3-Dichloro-5-[(2-methoxyethoxy)methoxy]-2-(phenylmethoxy)benzene;186805-81-2

Chemical Property of 1,3-Dichloro-5-[(2-methoxyethoxy)methoxy]-2-(phenylmethoxy)benzene

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 356.0582144
• Heavy Atom Count: 23
• Complexity: 301

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCOC1=CC(=C(C(=C1)Cl)OCC2=CC=CC=C2)Cl

Technology Process of 1,3-Dichloro-5-[(2-methoxyethoxy)methoxy]-2-(phenylmethoxy)benzene

There total 3 articles about 1,3-Dichloro-5-[(2-methoxyethoxy)methoxy]-2-(phenylmethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Methoxyethoxymethyl chloride (3970-21-6) + 2,6-dichloro-4-hydroxy-1-benzyloxybenzene (186805-79-8) → 2,6-dichloro-4-(methoxy ethoxy methoxy)-1-benzyloxybenzene (186805-81-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1080/00397919708004811

Reference yield:

2,6-dichloro-1,4-benzenediol (20103-10-0) → 2,6-dichloro-4-(methoxy ethoxy methoxy)-1-benzyloxybenzene (186805-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / K₂CO₃ / acetone / 12 h / Ambient temperature

2: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1080/00397919708004811

Reference yield:

2,6-dichloro-1,4-benzoquinone (697-91-6) → 2,6-dichloro-4-(methoxy ethoxy methoxy)-1-benzyloxybenzene (186805-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / satd. aq. Na₂S₂O₄ / CHCl₃

2: 66 percent / K₂CO₃ / acetone / 12 h / Ambient temperature

3: 92 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature

With sodium dithionite; sodium hydride; potassium carbonate; In tetrahydrofuran; chloroform; acetone;

DOI:10.1080/00397919708004811

upstream raw materials:

2-Methoxyethoxymethyl chloride

2,6-dichloro-4-hydroxy-1-benzyloxybenzene

2,6-dichloro-1,4-benzenediol

2,6-dichloro-1,4-benzoquinone

Downstream raw materials:

{3,5-Bis-[2,6-dichloro-4-(2-methoxy-ethoxymethoxy)-phenoxy]-4-methoxy-phenoxy}-tert-butyl-dimethyl-silane

bis 2,6-[(2',6'-dichloro-4'-methoxy ethoxy methoxy)phenoxy]-1,4-dimethoxybenzene

4-(tert-Butyl-dimethyl-silanyloxy)-2,6-bis-[2,6-dichloro-4-(2-methoxy-ethoxymethoxy)-phenoxy]-phenol

2,6-Bis-[2,6-dichloro-4-(2-methoxy-ethoxymethoxy)-phenoxy]-benzene-1,4-diol