[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane
CAS No.:321527-43-9
Molecular Formula:C₂₃H₃₃BrO₃Si
Molecular Weight:465.503
Hs Code.:

[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-<i>tert</i>-butyl-dimethyl-silane

Synonyms:[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

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Technology Process of [2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

There total 1 articles about [2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 760980-10-7
2-bromo-6-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-1-phenyl-ethyl]-phenol

: 74-88-4
methyl iodide

: 321527-43-9
[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 ℃; for 12h;
DOI:10.1002/1521-3773(20001002)39:19<3473::AID-ANIE3473>3.0.CO;2-E

Reference yield: 49.0%

: 73183-34-3
bis(pinacol)diborane

: 321527-43-9
[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

: 2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-1-phenyl-ethyl]-2-methoxy-phenyl}-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Guidance literature:: With potassium acetate; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In dimethyl sulfoxide; at 90 ℃; for 4h;
DOI:10.1002/1521-3773(20001002)39:19<3473::AID-ANIE3473>3.0.CO;2-E

Reference yield:

: 321527-43-9
[2-(3-bromo-2-methoxy-phenyl)-3-methoxy-2-phenyl-propoxy]-tert-butyl-dimethyl-silane

: C₃₀H₂₆N₂O₃

Guidance literature:: Multi-step reaction with 5 steps

1: 49 percent / KOAc / [Pd(dppf)Cl₂]*CH₂Cl₂ / dimethylsulfoxide / 4 h / 90 °C

2: 52 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane / 2 h / 85 °C

3: aq. HF / acetonitrile / 0.25 h / 0 °C

4: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 1 h / 0 - 25 °C

5: 45 percent / DBU; LiCl / acetonitrile / 6 h / 25 °C

With hydrogen fluoride; potassium acetate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; acetonitrile; 2: Suzuki reaction / 5: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/1521-3773(20001002)39:19<3473::AID-ANIE3473>3.0.CO;2-E