methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate
• CAS No.: 206994-52-7
• Molecular Formula: C₂₇H₂₅NO₅
• Molecular Weight: 443.499
• Mol file: 206994-52-7.mol

Synonyms:methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

Chemical Property of methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

There total 1 articles about methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloromethyl methyl ether (107-30-2) + (2S,3S)-3-hydroxy-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester (160882-77-9) → methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate (206994-52-7)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jo980078m

Reference yield: 94.0%

methylmagnesium bromide (75-16-1) + methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate (206994-52-7) → (2S,3S,4R)-4-Hydroxy-3-methoxymethoxy-4-methyl-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - -25 ℃; for 2.5h;

DOI:10.1021/jo980078m

Reference yield: 88.0%

methyl (2S,3S)-3-(methoxymethoxy)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate (206994-52-7) + 1,1-dibromomethane (74-95-3) → (2S,3R)-3-Methoxymethoxy-4-methylene-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid methyl ester (206994-55-0)

Guidance literature:

With zirconocene dichloride; zinc; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/jo980078m

upstream raw materials:

chloromethyl methyl ether

(2S,3S)-3-hydroxy-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester

Downstream raw materials:

methyl (2S,3S,4R)-4-hydroxy-3-(methoxymethoxy)-3-methyl-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate

(2S,3R)-3-Methoxymethoxy-4-methylene-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid methyl ester

[(2R,3R,4S)-4-Hydroxymethyl-3-methoxymethoxy-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidin-2-yl]-methanol

(2S,3S,4R)-4-Acetoxy-3-methoxymethoxy-3-methyl-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid methyl ester