[2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

Base Information

Chemical Name:[2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine
CAS No.:1569870-23-0
Molecular Formula:C₁₄H₁₅N₅O
Molecular Weight:269.306
Hs Code.:

Synonyms:[2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

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Chemical Property of [2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

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Technology Process of [2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

There total 3 articles about [2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1569870-19-4
8-iodo-[1,2,4]triazolo[4,3-b]pyridazine

: 55-81-2
4-Methoxyphenethylamine

: 1569870-23-0
[2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 105 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm401356t

Reference yield:

: 6698-57-3
6-chloro-1,2,4-triazolo<4,3-b>pyridazin-8-amine

: 1569870-23-0
[2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon / ethanol / 72 h / 20 °C / 2068.65 Torr / Inert atmosphere

2: isopentyl nitrite; diiodomethane / acetonitrile / 1 h / Reflux; Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 105 °C / Inert atmosphere

With diiodomethane; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401356t

Reference yield:

: 6583-39-7
[1,2,4]triazolo[4,3-b]pyridazin-8-ylamine

: 1569870-23-0
[2-(4-methoxy-phenyl)-ethyl]-[1,2,4]triazolo[4,3-b]pyridazin-8-yl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: isopentyl nitrite; diiodomethane / acetonitrile / 1 h / Reflux; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 105 °C / Inert atmosphere

With diiodomethane; potassium carbonate; isopentyl nitrite; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401356t