2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin

Base Information

• Chemical Name: 2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin
• CAS No.: 125438-24-6
• Molecular Formula: C₁₄H₂₁NO₄Si
• Molecular Weight: 295.411
• Mol file: 125438-24-6.mol

Synonyms:2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin

Chemical Property of 2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin

There total 1 articles about 2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trimethylsilyl cyanide (7677-24-9) + asaraldehyde (4460-86-0,14374-62-0) → 2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin (125438-24-6)

Guidance literature:

at 160 ℃; for 1h;

DOI:10.1021/jo00294a013

Reference yield:

2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin (125438-24-6) → 5,6-dimethoxyindole (14430-23-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) 1.0 M borane/THF complex 2) HCl / 1) THF, reflux, 3 h 2) CH₂Cl₂

2: 88 percent / pyridine / Ambient temperature

3: 68 percent / 1) 2percent KOH 2) H₂O / Ambient temperature; anodic oxidation; other substrates

4: 75 percent / p-TsOH*H₂O / benzene / 0.5 h / 60 °C

With tetrahydrofuran; pyridine; hydrogenchloride; potassium hydroxide; borane; water; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jo00294a013

Reference yield:

2,4,5-trimethoxybenzaldehyde O-(trimethylsilyl)cyanohydrin (125438-24-6) → 2-(2,4,5-trimethoxyphenyl)ethylamine hydrochloride (3166-78-7)

Guidance literature:

With tetrahydrofuran; hydrogenchloride; borane; Yield given. Multistep reaction; 1) THF, reflux, 3 h 2) CH₂Cl₂;

DOI:10.1021/jo00294a013

upstream raw materials:

trimethylsilyl cyanide

asaraldehyde

Downstream raw materials:

2-(2,4,5-trimethoxyphenyl)ethylamine hydrochloride

2,2,2-Trifluoro-N-[2-(2,4,5-trimethoxy-phenyl)-ethyl]-acetamide

5,6-dimethoxyindole

Refernces

• 1、 Swenton, John S.,Shih, Chuan,Chen, Chung-Pin,Chou, Chun-Tzer. "Preparation of Quinone Imine Ketals via Intramolecular Condensation of Amino-Substituted Quinone Monoketals. Anodic Oxidation Chemistry of Trifluoracetamide Derivatives of 1,4-Dimethoxybenzenes and 4-Methoxyphenols". . p. 2019 - 2026. Retrieved 2007/10/02.