1-(6-Chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethanone

Base Information

• Chemical Name: 1-(6-Chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethanone
• CAS No.: 90734-73-9
• Molecular Formula: C9H8 Cl N3 O
• Molecular Weight: 209.63
• DSSTox Substance ID: DTXSID50531879
• Wikidata: Q72434955
• Mol file: 90734-73-9.mol

Synonyms:90734-73-9;1-(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethanone;3-Acetyl-6-chloro-2-methylimidazo[1,2-b]pyridazine;1-(6-Chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethan-1-one;DTXSID50531879;MFCD09264542;AKOS015837758;AC-5173;CS-0085246;1-(6-chloro-2-methylimidazo[2,3-f]pyridazin-3-yl)ethanone

Chemical Property of 1-(6-Chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethanone

Chemical Property:

• Melting Point: 127～131℃
• Refractive Index: 1.666
• PSA: 47.26000
• Density: 1.44
• LogP: 1.89370
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 209.0355896
• Heavy Atom Count: 14
• Complexity: 248

Purity/Quality:

98%min ^*data from raw suppliers

3-Acetyl-6-chloro-2-methylimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(N2C(=N1)C=CC(=N2)Cl)C(=O)C

Technology Process of 1-(6-Chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethanone

There total 3 articles about 1-(6-Chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

chloroacetone (78-95-5) + (Z)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidoamide → 1-(6-chloro-2-methylimidazole[1,2-b]pyridazine-3-yl)ethanone (90734-73-9)

Guidance literature:

With potassium bromide; In ethanol; for 5h; Heating;

DOI:10.1016/j.bmcl.2004.02.008

Reference yield: 45.0%

1-bromoacetone (598-31-2) + N’-(6-chloropyridazin-3-yl)-N,N-dimethyl-acetamidine (68675-27-4) → 1-(6-chloro-2-methylimidazole[1,2-b]pyridazine-3-yl)ethanone (90734-73-9)

Guidance literature:

In ethanol; for 24h; Ambient temperature;

DOI:10.1055/s-1984-30802

Reference yield:

6-chloro-pyridazin-3-ylamine (5469-69-2) + 3-chloropentane-2,4-dione (1694-29-7) → 1-(6-chloro-2-methylimidazole[1,2-b]pyridazine-3-yl)ethanone (90734-73-9)

Guidance literature:

In ethanol; Reflux;

upstream raw materials:

1-bromoacetone

N’-(6-chloropyridazin-3-yl)-N,N-dimethyl-acetamidine

chloroacetone

6-chloro-pyridazin-3-ylamine

Downstream raw materials:

[4-(2-methyl-imidazo[1,2-b]pyridazin-3-yl)-pyrimidin-2-yl]-phenyl-amine

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