Technology Process of ethyl m-methoxy-atropate
There total 3 articles about ethyl m-methoxy-atropate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
Inert atmosphere;
ethyl 2-(3-methoxyphenyl)-2-oxoacetate;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 12h;
DOI:10.1021/ol202808n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere
1.2: 14 h / -78 - 20 °C / Inert atmosphere
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
2.2: 12 h / -78 - 20 °C
With
n-butyllithium; iodine; magnesium; diisopropylamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/ol202808n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 1 h / -78 °C / Schlenk technique; Inert atmosphere
2.1: potassium hexamethylsilazane / tetrahydrofuran / 1.25 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
2.2: 1 h / -78 °C / Inert atmosphere; Schlenk technique
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
DOI:10.1002/anie.201307245
