6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

Base Information

Chemical Name:6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate
CAS No.:478316-43-7
Molecular Formula:C₃₂H₂₇BrN₂O₆
Molecular Weight:615.48
Hs Code.:

Synonyms:6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

Suppliers and Price of 6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

There total 7 articles about 6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 59-88-1
phenylhydrazine hydrochloride

: 478316-39-1
6-[3-(N,N-dimethylamino)-2-(2-bromo-4,5-dimethoxyphenyl)acryloyl]-2,3-dimethoxyphenyl benzoate

: 478316-43-7
6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

Guidance literature:: With sodium carbonate; acetic acid; In methanol; water; at 145 ℃; pH=4;
DOI:10.1021/jo025767j

Reference yield: 91.0%

: 100-63-0
phenylhydrazine

: Benzoic acid 6-[(E)-2-(2-bromo-4,5-dimethoxy-phenyl)-3-dimethylamino-acryloyl]-2,3-dimethoxy-phenyl ester

: 478316-43-7
6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

Guidance literature:: With sodium carbonate; acetic acid; In methanol; water; at 140 ℃; pH=4;
DOI:10.1016/S0040-4039(00)00621-3

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 478316-43-7
6-[4-(2-bromo-4,5-dimethoxyphenyl)-2-phenyl-2H-pyrazol-3-yl]-2,3-dimethoxyphenyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / bromine / acetic acid / 3 h / 20 °C

2: SOCl₂ / toluene / 135 °C

3: 45 percent / AlCl₃ / CH₂Cl₂ / 55 °C

4: 88 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 20 °C

5: 81 percent / toluene / 90 °C

6: 91 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With sodium hydroxide; aluminium trichloride; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; bromine; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; toluene; 3: Friedel-Crafts acylation / 5: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j