N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Base Information

Chemical Name:N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine
CAS No.:1488427-09-3
Molecular Formula:C₂₈H₃₅FN₆OS
Molecular Weight:522.69
Hs Code.:

Synonyms:N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Suppliers and Price of N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

There total 11 articles about N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₃FN₆OS

: 1488427-09-3
N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.08.018

Reference yield:

: 56809-86-0
1-methyl-1H-indole-2-carbohydrazide

: 1488427-09-3
N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 3 h / 80 °C

2.1: potassium hydroxide / water / 2 h / 110 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C

3.2: 20 °C

4.1: trichlorophosphate / -5 °C

4.2: 1 h / 55 °C

5.1: acetic acid / 1,2-dichloro-ethane / 1 h

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 4.1: |Vilsmeier-Haack Formylation / 4.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018

Reference yield:

: 62-53-3
aniline

: 1488427-09-3
N-{{5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indol-3-yl}methyl}-3-morpholinopropan-1-amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydrogenchloride; sodium nitrite; tin(ll) chloride / -5 - 20 °C

2.1: acetic acid / ethanol / 1 h / 80 °C

3.1: polyphosphoric acid / toluene / 5 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C

5.1: hydrazine hydrate / ethanol / 0.75 h / 80 °C

6.1: ethanol / 3 h / 80 °C

7.1: potassium hydroxide / water / 2 h / 110 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C

8.2: 20 °C

9.1: trichlorophosphate / -5 °C

9.2: 1 h / 55 °C

10.1: acetic acid / 1,2-dichloro-ethane / 1 h

11.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; tin(ll) chloride; potassium hydroxide; sodium nitrite; trichlorophosphate; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 9.1: |Vilsmeier-Haack Formylation / 9.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018