1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

Base Information

Chemical Name:1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene
CAS No.:129084-01-1
Molecular Formula:C₂₂H₃₅FO₂Si
Molecular Weight:378.603
Hs Code.:

Synonyms:1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

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Chemical Property of 1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

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Technology Process of 1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

There total 7 articles about 1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131114-06-2
4-(tert-Butyl-dimethyl-silanyloxy)-2-(4-fluoro-3-methyl-phenyl)-6,6-dimethyl-cyclohex-2-enecarboxylic acid methyl ester

: 129084-01-1
1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 18h; Yield given;
DOI:10.1016/0223-5234(92)90095-I

Reference yield:

: 141-79-7
4-methyl-pent-3-en-2-one

: 129084-01-1
1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BF₃*OEt, 2.) Triton B / 1.) 0-5 deg C, 5 d, 2.) MeOH, reflux, 1 h

2: NaBH₄ / methanol / 1 h

3: imidazole / CH₂Cl₂

4: LAH / tetrahydrofuran / 18 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0223-5234(92)90095-I

Reference yield:

: 369-32-4
1-(4-fluoro-3-methylphenyl)ethanone

: 129084-01-1
1-(4-Fluoro-3-methylphenyl)-3-(t-butyldimethylsilyloxy)-5,5-dimethyl-6-hydroxymethylcyclohexene

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / NaH / diethyl ether / 2 h / Heating

2: 1.) BF₃*OEt, 2.) Triton B / 1.) 0-5 deg C, 5 d, 2.) MeOH, reflux, 1 h

3: NaBH₄ / methanol / 1 h

4: imidazole / CH₂Cl₂

5: LAH / tetrahydrofuran / 18 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; N-benzyl-trimethylammonium hydroxide; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0223-5234(92)90095-I