benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

Base Information

Chemical Name:benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate
CAS No.:1195781-33-9
Molecular Formula:C₂₁H₁₇FN₄O₃
Molecular Weight:392.389
Hs Code.:

Synonyms:benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

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Chemical Property of benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

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Technology Process of benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

There total 7 articles about benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1195781-31-7
benzyl (4-{[(6Z)-1-(2-amino-2-oxoethyl)-6-{[(4-methylphenyl)sulfonyl]imino}-1,6-dihydropyridin-3-yl]oxy}-2-fluorophenyl)carbamate

: 1195781-33-9
benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

Guidance literature:: benzyl (4-{[(6Z)-1-(2-amino-2-oxoethyl)-6-{[(4-methylphenyl)sulfonyl]imino}-1,6-dihydropyridin-3-yl]oxy}-2-fluorophenyl)carbamate; With trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

With sodium hydroxide; In ethanol; water; at 20 ℃; for 4h;

Reference yield:

: 1195781-27-1
benzyl {4-[(6-aminopyridin-3-yl)oxy]-2-fluorophenyl}carbamate

: 1195781-33-9
benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 3 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

3.3: 4 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1195781-33-9
benzyl {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]-2-fluorophenyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 6 h / 20 °C

3.1: water; iron; calcium chloride / ethanol / 8 h / Reflux

4.1: pyridine / 3 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

6.3: 4 h / 20 °C

With pyridine; water; iron; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; calcium chloride; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;