tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate
• CAS No.: 1092563-72-8
• Molecular Formula: C₂₀H₃₄BN₃O₄
• Molecular Weight: 391.319

Synonyms:tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl4-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}piperidine-1-carboxylate 97.0% ^*data from reagent suppliers

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Technology Process of tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

→ tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate (1092563-72-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

Reference yield: 43.0%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate (161975-39-9) → tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate (1092563-72-8)

Guidance literature:

pyrazole-4-boronic acid pinacol ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 35 ℃; for 1h;

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate; In N,N-dimethyl-formamide; at 0 - 35 ℃; for 18h;

Reference yield:

4-(4-bromo-pyrazol-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester (877401-26-8) + bis(pinacol)diborane (73183-34-3) → tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate (1092563-72-8)

Guidance literature:

With potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; at 80 ℃;

upstream raw materials:

4-(4-bromo-pyrazol-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

bis(pinacol)diborane

pyrazole-4-boronic acid pinacol ester

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

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