N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

Base Information

• Chemical Name: N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide
• CAS No.: 145942-08-1
• Molecular Formula: C₁₃H₁₆F₂N₄OS
• Molecular Weight: 314.359
• Mol file: 145942-08-1.mol

Synonyms:N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

Chemical Property of N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide

There total 1 articles about N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl> disulfide (136598-92-0) → N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide (145942-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₂ / CH₂Cl₂; CCl₄ / 0.33 h / 0 °C

2: CH₂Cl₂; CCl₄; toluene / 0.5 h / 0 °C

With chlorine; In tetrachloromethane; dichloromethane; toluene;

DOI:10.1248/cpb.42.85

Reference yield:

N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide (145942-08-1) → N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4(1H-1,2,4-triazol-1-yl)-2-butane]sulfonamide (145942-09-2)

Guidance literature:

With potassium permanganate; In acetone; Ambient temperature;

DOI:10.1248/cpb.42.85

Reference yield:

N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-2-butane]sulfenamide (145942-08-1) → (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-N-methyl-N-(3-pyridylmethyl)-4-(1H-1,2,4-triazol-1-yl)-2-butanesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KMnO₄ / acetone / Ambient temperature

2: 40 percent / MeONa / methanol / 4 h / 60 °C

With potassium permanganate; sodium methylate; In methanol; acetone;

DOI:10.1248/cpb.42.85

upstream raw materials:

bis<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl> disulfide

Downstream raw materials:

N-methyl-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4(1H-1,2,4-triazol-1-yl)-2-butane]sulfonamide