4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester

Base Information

Chemical Name:4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester
CAS No.:1428884-31-4
Molecular Formula:C₃₅H₃₀N₂O₃
Molecular Weight:526.635
Hs Code.:

Synonyms:4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester

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Chemical Property of 4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester

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Technology Process of 4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester

There total 2 articles about 4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 201230-82-2
carbon monoxide

: 922-67-8
propynoic acid methyl ester

: 1-methyl-5-phenyl-1H-indole

: 1428884-21-2
4-(1-methyl-5-phenylindol-3-yl)-4-oxo-(2E)-butenoic acid methyl ester

: 1428884-31-4
4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester

Guidance literature:: With tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 105 ℃; for 15h; under 15514.9 Torr; regioselective reaction; Autoclave;
DOI:10.1021/ol400722h

Reference yield:

: 66616-72-6
5-phenyl-1H-indole

: 1428884-31-4
4-(1-methyl-5-phenylindol-3-yl)-4-oxo-2-(1-methyl-5-phenylindol-3-yl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 15 h / 105 °C / 15514.9 Torr / Autoclave

With tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); sodium hydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol400722h