[1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

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Chemical Name:[1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate
CAS No.:137326-16-0
Molecular Formula:C₁₇H₂₃NO₆
Molecular Weight:337.373
Hs Code.:

Synonyms:[1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

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Chemical Property of [1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

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Technology Process of [1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

There total 11 articles about [1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 137326-15-9
Benzoic acid (1S,6R,7R,8S,9S,9aR)-7,8,9-tris-benzyloxy-6-benzyloxymethyl-octahydro-quinolizin-1-yl ester

: 137326-16-0
[1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

Guidance literature:: With hydrogen; palladium; In acetic acid;
DOI:10.1016/S0040-4039(00)79409-3

Reference yield:

: Octahydro-7,8,9-tris (phenylmethoxy)-6-[(phenylmethoxy)methyl]-2H-quinolizin1-ol benzoate (ester)

: 137326-16-0
[1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

Guidance literature:: palladium; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; acetic acid;

Reference yield:

: 110205-71-5
2,6-dideoxy-2,6-imino-1,3,4,5-tetrakis-O-(phenylmethyl)-D-glycero-L-gulo-heptitol

: 137326-16-0
[1S-(1α,2β,3α,4β,9α,9aβ) ]-octahydro-4-(hydroxymethyl)-2H-quinolizine-1,2,3,9-tetrol 9-benzoate

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N

2: AlH₃ / tetrahydrofuran

3: (COCl)2, DMSO

4: diethyl ether

5: DMAP

6: 1) BH₃*Me₂S 2) H₂O₂

7: cyclohexene / Pd(OH)2 / methanol

8: MsCl, pyridine

9: 85 percent / H₂ / Pd-black / acetic acid

With pyridine; aluminium hydride; dmap; oxalyl dichloride; dimethylsulfide borane complex; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; cyclohexene; palladium dihydroxide; palladium; In tetrahydrofuran; methanol; diethyl ether; acetic acid;
DOI:10.1016/S0040-4039(00)79409-3