<<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1)

Base Information

• Chemical Name: <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1)
• CAS No.: 117023-85-5
• Molecular Formula: C₄H₄O₄*2C₃₁H₃₄F₂N₂O₅
• Molecular Weight: 1221.31

Synonyms:<<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1)

Chemical Property of <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1)

Chemical Property:

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Technology Process of <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1)

There total 8 articles about <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

Ethyl oxalyl chloride (4755-77-5) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) + 1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol (117023-80-0) → <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1) (117023-85-5)

Guidance literature:

With triethylamine; 1) benzene, room temperature, overnight;

DOI:10.1021/jm00121a022

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1) (117023-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / acetone / 24 h / Heating

2: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

3: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

4: 33 percent / 1) triethylamine / 1) benzene, room temperature, overnight

With hydrogen; sodium carbonate; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; acetone; butan-1-ol;

DOI:10.1021/jm00121a022

Reference yield:

1-(3-Chloropropoxy)-4-nitrobenzene (79096-54-1) → <<4-<3-<4--1-piperidinyl>propoxy>phenyl>amino>oxoacetic acid ethyl ester (E)-2-butenedioate (2:1) (117023-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

2: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

3: 33 percent / 1) triethylamine / 1) benzene, room temperature, overnight

With hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; butan-1-ol;

DOI:10.1021/jm00121a022

upstream raw materials:

Ethyl oxalyl chloride

(2E)-but-2-enedioic acid

1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

4-nitro-phenol

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