1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Base Information

• Chemical Name: 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole
• CAS No.: 264883-44-5
• Molecular Formula: C₃₂H₃₈N₄O₂
• Molecular Weight: 510.679
• Mol file: 264883-44-5.mol

Synonyms:1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Chemical Property of 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

There total 6 articles about 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole (264883-42-3) → 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole (264883-44-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(00)00454-6

Reference yield:

methyl 4-bromomethyl-2-methoxybenzoate (74733-27-0) → 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole (264883-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / dimethylsulfoxide

2: 120 °C

3: 62 percent / LAH / tetrahydrofuran

With potassium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; dimethyl sulfoxide; 1: Alkylation / 2: aminolysis / 3: Reduction;

DOI:10.1016/S0960-894X(00)00454-6

Reference yield:

(3-methylpyridin-4-yl)carbamic acid tert-butyl ester (180253-65-0) → 1-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole (264883-44-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: BuLi

1.2: HCl / 50 - 55 °C

2.1: KOH / dimethylsulfoxide

3.1: 120 °C

4.1: 62 percent / LAH / tetrahydrofuran

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; dimethyl sulfoxide; 1.1: cyclocondensation / 1.2: acidolysis / 2.1: Alkylation / 3.1: aminolysis / 4.1: Reduction;

DOI:10.1016/S0960-894X(00)00454-6

upstream raw materials:

1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

methyl 4-bromomethyl-2-methoxybenzoate

(3-methylpyridin-4-yl)carbamic acid tert-butyl ester

N-Methoxy-N-methyl-4-[2-(1-pyrrolidinyl)ethoxy]-benzamide