1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Base Information

Chemical Name:1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole
CAS No.:264883-42-3
Molecular Formula:C₃₂H₃₆N₄O₃
Molecular Weight:524.663
Hs Code.:

Synonyms:1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

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Chemical Property of 1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

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Technology Process of 1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

There total 5 articles about 1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 123-75-1
pyrrolidine

: 264883-50-3
methyl 2-Methoxy-4-[[2-[4-[2-(1-pyrrolidinyl)ethoxy]-phenyl]-5-azaindol-1-yl]methyl]benzoate

: 264883-42-3
1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Guidance literature:: at 120 ℃; for 48h;

Reference yield:

: 74733-27-0
methyl 4-bromomethyl-2-methoxybenzoate

: 264883-42-3
1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / dimethylsulfoxide

2: 120 °C

With potassium hydroxide; In dimethyl sulfoxide; 1: Alkylation / 2: aminolysis;
DOI:10.1016/S0960-894X(00)00454-6

Reference yield:

: 180253-65-0
(3-methylpyridin-4-yl)carbamic acid tert-butyl ester

: 264883-42-3
1-[3-methoxy-4-(1-pyrrolidinylcarbonyl)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-5-azaindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi

1.2: HCl / 50 - 55 °C

2.1: KOH / dimethylsulfoxide

3.1: 120 °C

With potassium hydroxide; n-butyllithium; In dimethyl sulfoxide; 1.1: cyclocondensation / 1.2: acidolysis / 2.1: Alkylation / 3.1: aminolysis;
DOI:10.1016/S0960-894X(00)00454-6